Anti-inflammatory and analgesic effect of an alkaloid-fixed oil mix from Linumusitatisimum seeds in vivo

Abstract

Inflammation is an immune response to chemical, physical or biological aggression. The comprehension of the several pro-inflammatory and pro-resolving process may lead to the development of new functional drugs instead of the conventional ones. However, Inflammation reaction is conventionally treated by steroidal and nonsteroidal anti-inflammatory drugs. These medications may be useless because of their side effects. In this study, we aim to evaluate the anti-inflammatory and analgesic effect of alkaloid /fixed oil mixture (AO) from flaxseeds in-vivo. Three doses of AO mix (50, 100 and 200 mg/kg) were used in several anti-inflammatory and analgesic tests. The obtained results had shown that the AO mix presents a potential anti-inflammatory and analgesic activities. These results highlight the therapeutic potential of alkaloids and fixed oils combination. Additionally, to other research, the present study supports the anti-inflammatory and analgesic effects of flax seeds with an original contribution by combining alkaloids and fixed oil from Linumusitatissimum