Flaxseed oil supplementation improves lipid levels in the liver of aged obese rats
Keywords:
Linseed oil, Cafeteria diet, Lipid, obesity, aged rats, liverAbstract
Introduction: Flaxseed (Linum usitatissimum L.) oil is an excellent functional oil containing various unsaturated fatty acids, mainly composed of linolenic acid, which is believed to have a variety of beneficial physiological and functional properties. This study was conducted to evaluate the hepato protective effects of flaxseed oil. The aim was to study how dietary linseed oil modulates lipid level in the liver of aged obese rats.
Methods: aged rats were fed a control (C) or a Cafeteria (CAF) diet enriched or non-enriched with linseed oil at 5%. Changes in cholesterol (TC) and triglyceride (TG) and LCAT activity levels in the liver were determined at the end of the experiment.
Results: The cafeteria diet led to higher weight liver and hyperlipidemia, contents in liver of aged obese rats. Linseed oil (LO) supplementation modulates liver tissue TC and TG contents in both control and obese aged rats , with beneficial effects resulting in lower liver weight, decreased in TC,TG, low density lipoprotein-high density lipoprotein1(LDL-HDL-C), and increased in serum LCAT activity
Conclusion: The supplement of linseed oil in the diet of aged obese rats is effective in amelioration of [1]lipid liver profile in aged rats, which might contribute to prevent obesity and dyslipidemia.
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