Overview of the therapeutic and or pharmaceutical effects of olive mill waste water on the gastroduodenal mucosa injuries
Keywords:
Olive production and derivates - Olive mill waste water - Gastroduodenal mucosa lesions - Helicobacter pylori - Bioactive compounds - Healing Effect.Abstract
Introduction: The purpose of this study is to review the literature supporting the use of olive mill waste water
(OMW) in the management of gastroduodenal mucosa lesions and or ulcer.
Methods: Current benchmark data is collected from the DSA for the running year. The survey process is
inspired by using various databases to summarise credible research in the in-vivo and in-vitro literature through
the systematic use of electronic databases and resources such as Google scholar, Springer link, Science Direct
and PubMed. To provide a full and wide scope of relevant evidence, the inclusion criteria for this review were
set to filter out studies that assessed the relationship between OMW and gastroduodenal mucosa lesions and or
ulcer.
Results: A variety of literature was reviewed in order to obtain as much information as possible, and a total of
43 studies were selected for inclusion in this overview. This paper focuses on the relationship between OMW
and healing effects of gastroduodenal ulcer. It would be useful to scrutinize the data resulting from the study of
the physiological and metabolic effects. The meta-analysis has shown that polyphenols from Olea europaea, and
therefore those from their OMW, have numerous biological activities, both in terms of primary and secondary
prevention, in particular gastroprotective and anti-ulcer activity. Previous research has suspected that OMW
polyphenols may have both anti-inflammatory and antioxidant properties, which may help to protect the stomach
lining from damage and reduce the risk of developing ulcers. They may also help by suppressing the
proliferation of Helicobacter pylori, widely diagnosed in clinical development of gastric wound ulcer.
Conclusion: According to diverse studies, OMW compounds have shown potential healling activity. Its antiinflammatory,
antioxidant and antibacterial properties may help to protect the stomach mucosa and reduce the
risk of developing lesions of the gastroduodenal mucosa. However, further research is needed to fully clarify
their mechanisms of their potential health benefits.
References
- Abdellah F, Silarbi T, Zouidi F, Hamden K (2024). Effects of Olea oleaster leaf extract and purified oleuropein
on ethanol-induced gastric ulcer in male Wistar rats. Iranian Journal of Basic Medical Sciences 27(8) : 996.
https://doi: 10.22038/IJBMS.2024.76135.16474
- Aggoun M, Arhab R, Cornu A, Portelli J, Barkat M, Graulet B (2016). Olive mill wastewater microconstituents
composition according to olive variety and extraction process. Food chemistry 209 : 72-80.
https://doi.org/10.1016/j.foodchem.2016.04.034
- Albini A, Calabrone L, Albini F, Corradino P, Cristoni S, Noonan DM (2024). A nutraceutical supplement
derived from olive oil byproducts exhibits potential cancer preventive properties in preclinical studies and
increases vitamin D levels. Cancer Research 84(6_Supplement) : 7298-7298. https://doi.org/10.1158/1538-
AM2024-7298
- Ali SI, Salama A (2024). Natural Immunomodulatory Agents as a Complementary Therapy for
Poxviruses. Poxviruses : 337-354. https://doi.org/10.1007/978-3-031-57165-7_22
- Al-Rimawi F, Sbeih M, Amayreh M, Rahhal B, Mudalal S (2024). Evaluation of the antibacterial and antifungal
properties of oleuropein, olea Europea leaf extract, and thymus vulgaris oil. BMC Complementary Medicine and
Therapies 24(1) : 297. https://doi.org/10.1186/s12906-024-04596-x
- Attard K, Lia F (2024). The Antioxidant and Bioactive Potential of Olive Mill Waste. IntechOpen. https://doi:
5772/intechopen.1004127
- Bartkowiak-Wieczorek J, Madry E (2024). Natural Products and Health. Nutrients 16 : 415.
https://doi.org/10.3390/ nu16030415
- Bernini R, Campo M, Cassiani C, Fochetti A, Ieri F, Lombardi, et al., (2024). Polyphenol-Rich Extracts from
Agroindustrial Waste and Byproducts: Results and Perspectives According to the Green Chemistry and Circular
Economy. J. Agric. Food Chem 72 (23) : 12871–12895. https://doi.org/10.1021/acs.jafc.4c00945
- Calahorra J, Blaya-Cánovas JL, Castellini-Pérez O, Aparicio-Puerta E, Cives-Losada C, Marin JJ, et al., (2024).
Unlocking the effective alliance of β-lapachone and hydroxytyrosol against triple-negative breast cancer
cells. Biomedicine & Pharmacotherapy 174 : 116439. https://doi.org/10.1016/j.biopha.2024.116439
- Chen S, Cai T, Lu J, Le J, Zhang J, Yao Q, Chen L (2024a). Hydroxytyrosol promotes random skin flap survival
by activating SIRT1-mediated enhancement of autophagy. Journal of Functional Foods 121 : 106443.
https://doi.org/10.1016/j.jff.2024.106443
- Chen Y, Zheng Y, Wen X, Huang J, Song Y, Cui Y, Xie X (2024b). Anti-inflammatory effects of Olive (olea
europaea L.) fruit extract in LPS-stimulated RAW264. 7 cells via MAPK and NF-κB signal pathways. Molecular
Biology Reports 51(1) : 774. https://doi: 10.18632/aging.100691
- Costa LCMC, Carvalho MG, Pereira ACGC, Neto RGT, Figueiredo LCA, Barros -Pinheiro M (2024). Diagnostic
Methods for Helicobacter pylori. Med Princ Pract 33:173-184. https:// 10.1159/000538349
- Dabravolski SA, Pleshko EM, Sukhorukov VN, Glanz VY, Sobenin IA, Orekhov AN (2024). Use of Olivesderived
Phytochemicals for Prevention and Treatment of Atherosclerosis: An Update. Current Topics in
Medicinal Chemistry 24(25): 2173-2190. https://doi.org/10.2174/0115680266314560240806101445
- Deng Y, Zhou J, Wang B, Xu X, Huang T, Xu Z, Zhao C (2024). Optimization of Different Extraction Methods
for Phenolic Compound Verbascoside from Chinese Olea europaea Leaves Using Deep Eutectic Solvents:
Impact on Antioxidant and Anticancer Activities. Molecules 29(17) : 4219.
https://doi.org/10.3390/molecules29174219
- DSA (2025). Tlemcen Agricultural Services Department. Wilaya of Tlemcen-Algeria.
- FAO (2017). Food And Agriculture Organization. https://www.fao.org/countryprofiles.
- Foti P, Romeo FV, Russo N, Pino A, Vaccalluzzo A, Caggia C, Randazzo CL (2021). Olive Mill Wastewater as
Renewable Raw Materials to Generate High Added-Value Ingredients for Agro-Food Industries. Appl Sci 11 :
https://doi.org/10.3390/ app11167511
- Gabbia D, Sayaf K, Zanotto I, Colognesi M, Frion-Herrera Y, Carrara M, et al., (2024). Tyrosol attenuates
NASH features by reprogramming the hepatic immune milieu. European Journal of Pharmacology 969 : 176453.
https://doi.org/10.1016/j.dld.2023.01.130
- Giurranna E, Nencini F, Bettiol A, Borghi S, Argento FR, Emmi G, et al., (2024). Dietary Antioxidants and
Natural Compounds in Preventing Thrombosis and Cardiovascular Disease. International Journal of Molecular
Sciences 25(21) : 11457. https://doi.org/10.3390/ijms252111457
- Gonçalves M, Aiello A, Rodríguez-Pérez M, Accardi G, Burgos -Ramos E, Silva P (2024a). Olive Oil
Components as Novel Antioxidants in Neuroblastoma Treatment: Exploring the Therapeutic Potential of
Oleuropein and Hydroxytyrosol. Nutrients 16(6) : 818. https://doi.org/10.3390/nu16060818
- Gonçalves M, Vale N, Silva P (2024b). Neuroprotective Effects of Olive Oil: A Comprehensive Review of
Antioxidant Properties. Antioxidants 13(7) : 762. https://doi.org/10.3390/antiox13070762
- Gouvinhas I, Machado N, Sobreira C, Domínguez-Perles R, Gomes S, Rosa E, Barros NA (2017). Critical
Review on the Significance of Olive Phytochemicals in Plant Physiology and Human Health. Molecules (Bas el,
Switzerland 22(11) : 1986. https://doi.org/10.3390/molecules22111986
- Harun N, Adnyana IK, Damayanti S, Kurniati NF (2025). Administration of oleuropein or hydroxytyrosol
improves diabetic markers in obese mice. Journal of Pharmacy & Pharmacognosy Research 13(2) : 513-526.
https://doi.org/10.3390/antiox8060188
- Khalil AA, Rahman MM, Rauf A, Islam MR, Manna SJ, Khan AA et al., (2024). Oleuropein: Chemistry,
extraction techniques and nutraceutical perspectives -An update. Critical Reviews in Food Science and
Nutrition 64(27) : 9933-9954. https://doi.org/10.1080/10408398.2023.2218495
- Lamarque D, Burucoa C, Courillon-Mallet A et al., (2012). Révision des recommandations françaises sur la prise
en charge de l9infection par Helicobacter pylori. Hepato Gastro 19 : 475-502.
- Laveriano‐Santos EP, Vallverdú‐Queralt A, Bhat R, Tresserra‐Rimbau A, Gutiérrez‐Alcalde E,
Campins‐Machado FM et al., (2024). Unlocking the potential of olive residues for functional purposes: update on
human intervention trials with health and cosmetic products. Journal of the Science of Food and
Agriculture 104(7) : 3816-3822. https://doi.org/10.1002/jsfa.13451
- Li X, Hou Y, Zou H, Wang Y, Xu Y, Wang L et al., (2024). Unraveling the efficacy of verbascoside in thwarting
MRSA pathogenicity by targeting sortase A. Applied Microbiology and Biotechnology 108(1) : 1-15.
https://doi.org/10.1007/s00253-024-13202-6
- Malik TF, Gnanapandithan K, Singh K (2024). Peptic Ulcer Disease. In: StatPearls. Treasure Island (FL):
StatPearls Publishing. PMID: 30521213
- Mao Q, Zhang H, Zhang Z, Lu Y, Pan J, Guo D et al., (2024). Co-decoction of Lilii bulbus and Radix
Rehmannia Recens and its key bioactive ingredient verbascoside inhibit neuroinflamma tion and intestinal
permeability associated with chronic stress -induced depression via the gut microbiota-brain
axis. Phytomedicine 129 : 155510. https://doi.org/10.1016/j.phymed.2024.155510
- Misal SS, Bhor BV, Chelakara SR (2024). Structural Insights into Potent Anti-ulcer Agents for the Eradication of
Helicobacter pylori. Anti-Infective Agents 22(5) : 29-42. https://doi.org/
2174/0122113525296549240402074618
- Moghadam ZSM, Mansour FN, Naseroleslami M, Niri NM (2024). Preparation, characterization, and evaluation
of the antimicrobial effects of farnesol-and tyrosol-bearing nanoniosomes on Pseudomonas aeruginosa,
Staphylococcus aureus, and Escherichia coli. Medical Journal of Tabriz University of Medical Sciences.
https://doi.org/:10.34172/mj.2024.024
- Mohamed NA, Hussein MM, Ahmed OM, Al-Jameel SS, Al-Muzafar HM, Amin KA, Abdou HM (2024).
Oleuropein ameliorates hyperlipidemia, oxidative stress, inflammatory and liver dysfun ction biomarkers, in
streptozotocin-induced diabetic rats. J Appl Pharm Sci 14(09): 227–
http://doi.org/10.7324/JAPS.2024.167994
- Naseroleslami M, Khakpai F, Jafari-Rastegar N, Hosseininia HS, Mousavi-Niri N (2024). The modulatory effects
of tyrosol and nano-tyrosol on anxiety-like behavior and emotional memory in streptozotocin-induced diabet ic
rats. NeuroReport 35(16) : 1011-1018. http://doi.org/ 10.1097/WNR.0000000000002061
- Pongkitwitoon B, Putalun W, Triwitayakorn K, Kitisripanya T, Kanchanapoom T, Boonsnongcheep P (2024).
Anti-inflammatory activity of verbascoside-and isoverbascoside-rich Lamiales medicinal plants. Heliyon 10(1).
e23644. https://doi.org/10.1016/j.heliyon.2023.e23644
- Reyes-Corral M, Gil-González L, González-Díaz Á, Tovar-Luzón J, Ayuso MI, Lao-Pérez M et al., (2024).
Pretreatment with oleuropein protects the neonatal brain from hypoxia-ischemia by inhibiting apoptosis and
neuroinflammation. Journal of Cerebral Blood Flow & Metabolism 0271678X241270237.
https://doi.org/10.1177/0271678X2412702
- Salucci S, Burattini S, Versari I, Bavelloni A, Bavelloni F, Curzi D et al., (2024). Morpho-Functional Analyses
Demonstrate That Tyrosol Rescues Dexamethasone-Induced Muscle Atrophy. Journal of Functional Morphology
and Kinesiology 9(3). https://doi.org/10.3390/jfmk9030124
- Singh K, Kumar R, Singh AP, Malhotra M, Rani R (2024); Peptic Ulcer: A review. Int. J. Med. Phar. Drug Re
(2) : 38-46. https://creativecommons.org/licenses/by/4.0
- Soares TF, Alves RC, Oliveira MBP (2024). From Olive Oil Production to By-Products: Emergent Technologies
to Extract Bioactive Compounds. Food Reviews International : 1-28.
https://doi.org/10.1080/87559129.2024.2354331
- Vadakutt J, Doshi GM (2024). Enhancing gastric ulcer management: Novel insights from terazosin-pantoprazole
combination therapy. Indian Drugs 61(1) :77. https://doi.org/ 10.53879/id.61.01.14392
- Waldum H. (2024).The Role of The Gastric Juice in the Defence Against Common and Serious Diseases. J
Gastro Hepato 10(12): 1-11.
- Wang Q, Tripodi N, Valiukas Z Bell SM, Majid A, De Courten B et al., (2024). The protective role of carnos ine
against type 2 diabetes ‐induced cognitive impairment. Food Science & Nutrition 12(6) : 3819-3833.
https://doi.org/10.1002/fsn3.4077
- Yadav P, Vengoji R, Jain M, Batra SK, Shonka N (2024). Pathophysiological role of histamine signaling and it s
implications in glioblastoma. Biochimica et Biophysica Acta (BBA)-Reviews on Cancer 189146.
https://doi.org/10.1016/j.bbcan.2024.189146
- Yılmaz G, Zdemir F (2024). Novel Anti-tumor Strategy for Breast Cancer: Synergistic Role of Oleuropein with
Paclitaxel Therapeutic in MCF-7 Cells. Anti-Cancer Agents in Medicinal Chemistry-Anti-Cancer Agents) 24(3) :
-234. https://doi.org/10.2174/0118715206284107231120063630
- Yücer R, Schröder A, Topçu G, Efferth T (2024). Identification of Anti-Inflammatory and Anti-Cancer
Compounds Targeting the NF-κB-NLRP3 Inflammasome Pathway from a Phytochemical Library of the Sideritis
Genus. Journal of Ethnopharmacology : 119074. https://doi.org/10.1016/j.jep.2024.119074
- Zbakha H, El Abbassi A (2012). Potential use of olive mill wastewater in the preparation of functional
beverages: A review. Journal Of Functional Foods (4) : 53 - 65. https://doi.org/10.1016/j.jff.2012.01.002
- Zoubdane N, Abdo RA, Nguyen M, Bentourkia MH, Turcotte EE, Berrougui H et al., (2024). High Tyros ol and
Hydroxytyrosol Intake Reduces Arterial Inflammation and Atherosclerotic Lesion Microcalcification in Healthy
Older Populations. Antioxidants 13(1) : 130. https://doi.org/10.3390/antiox13010130