Anti gastric ulcer activity of the root bark of Osyris Alba L skell Santalaceae from the south ouest of Tlemcen (Algeria)
Keywords:
Os yris alba L Skeel, root bark, decocted, anti gastric ulcer, PI, IU, Wistar ratsAbstract
Introduction: The work presented in this paper contributes to the valuation of the wound healing power of the decocted of the plant Osyris alba L Skeel which is belonging to the Santalaceae family, its root is traditionally used by the local population for treatment of gastric ulcers, rheumatism and its decoction is taken as a fortifier.
Methods: The qualitative analysis of phenols compounds was carried out by high performance liquid chromatography coupled with a diode array detector on a reversed phase column (RP-HPLC-PDA). The gastric antiulcer activity consisted of causing gastric ulcers by administering orally the ulcerogenic mixture for each Wistar rat and then to evaluate the healing power of Osyris alba decoction in the treatment of gastric ulcers.
Results: According to the study the curative effect of the aqueous extract on gastric ulcer, evaluated in Wistar rats, showed a wound healing power with an estimated percentage inhibition of 98.67% which exceeds the ranitidine (standard).
Conclusion: These results have enabled us to promote Osyris alba L Skeel as an antiulcer plant which is due to the presence of phenolic compounds (Gallic acid and Quercetin) which are analyzed by HPLC DA.
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