Extraction characterization and investigation of breadfruit seed oil for possible pharmaceutical application

Authors

  • Romanus CHIJIOKE OMEH Department of Pharmaceutics and Pharmaceutical Technology, Enugu State University of Science and Technology, Enugu State, Nigeria;
  • Jude IBEABUCHI ALI Department of Pharmaceutical Chemistry, Enugu State University of Science and Technology, Enugu State, Nigeria;
  • Assumpta ADAOBI OMEH Department of Biochemistry, Faculty of Biological Sciences, Federal University of Technology, Owerri, Imo State, Nigeria;
  • Lydia UGORJI Department of Pharmaceutical Technology and Industrial Pharmacy, University of Nigeria Nsukka, Enugu State, Nigeria
  • Josephat OGBONNA4 Department of Pharmaceutical Technology and Industrial Pharmacy, University of Nigeria Nsukka, Enugu State, Nigeria

DOI:

https://doi.org/10.46325/jnpra.v3i01.48

Keywords:

extraction; polyunsaturated; chromatography; degumming; hydrolysis; pharmaceutical.

Abstract

This work aimed at extracting, characterizing and evaluating breadfruit seed oil for potential pharmaceutical applications. The breadfruit oil was purified by degumming, bleaching, neutralization and enzyme hydrolysis. The oil was characterized for the yield, pH value, iodine, acid, peroxide and saponification values and fatty acid composition. Results obtained were interpreted with respect to their relevance in pharmaceutical formulations.The percentage yields of the oil from the soxhlet procedure was 23.54 % while the yield from the cold maceration extraction method was 13.69 %. The iodine, acid, peroxide and saponification values were, 17.50 ± 0.05, 3.40 ± 0.33, 7.20 ± 0.08, and 236.46 ± 0.02 respectively. Gas chromatographic- infrared studies identified five polyunsaturated long chain fatty acids. The breadfruit oil has good edible properties by virtue of its moderate acid and peroxide values. Its high iodine and low saponification values may necessitate the addition of antioxidants in pharmaceutical formulations containing breadfruit oil. The results obtained in this work suggest that breadfruit oil has good potential for pharmaceutical applications.

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Published

2023-04-02

How to Cite

Romanus CHIJIOKE OMEH, Jude IBEABUCHI ALI, Assumpta ADAOBI OMEH, Lydia UGORJI, & Josephat OGBONNA4. (2023). Extraction characterization and investigation of breadfruit seed oil for possible pharmaceutical application. Journal of Natural Product Research and Applications, 3(01), 4–17. https://doi.org/10.46325/jnpra.v3i01.48

Issue

Vol. 3 No. 01 (2023): Journal of Natural Product Research and Applications

Section

Research article

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