Maceration, microwave assisted and ultrasound assisted extraction of phenolic compounds from Tunisian Limoniastrum monopetalum: kinetic modeling and chemical analysis


  • Olfa Khedher University of Sfax, Faculty of Sciences of Sfax, Organic Chemistry Laboratory (LR17ES08), Sfax 3029, Tunisia
  • Manel Elakremi University of Gafsa, Faculty of Sciences of Gafsa, Gafsa 2112, Tunisia
  • Ridha Ben Salem University of Sfax, Faculty of Sciences of Sfax, Organic Chemistry Laboratory (LR17ES08), Sfax 3029, Tunisia
  • Younes Moussaoui University of Gafsa, Faculty of Sciences of Gafsa, Gafsa 2112, Tunisia



Limoniastrum monopetalum; RP-HPLC; phenolic compounds; UAE; MAE.


Maceration, ultrasound-assisted extraction (UAE), and microwave-assisted extraction (MAE) were investigated in this study, focusing on the selectivity towards phenolic compounds in ethanol extracts from Limoniastrum monopetalum leaves using the Folin-Ciocalteu method and kinetic models of extractions. Moreover, several phenolic compounds were identified by RP-HPLC. Results showed that total polyphenol compounds (TPC) under the MAE conditions (ethanol, 700 W microwave power, 60 s extraction time, and 1 mL/g solvent-to-solid ratio) were 75.707 mg GAE/100 g dried sample in only one minute of extraction. We conclude that MAE is a promising extraction method for polyphenols. Model results were correlated with mathematical models of the extraction process. Six phenolic acids and three flavonoids were identified by HPLC–DAD. MAE is a valuable and green analytical methodology for the investigation of phenolic components in natural plants.


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How to Cite

Olfa Khedher, Manel Elakremi, Ridha Ben Salem, & Younes Moussaoui. (2024). Maceration, microwave assisted and ultrasound assisted extraction of phenolic compounds from Tunisian Limoniastrum monopetalum: kinetic modeling and chemical analysis. Journal of Natural Product Research and Applications, 3(02), 23–33.