Effect of Citrullus colocynthis oil on the lipid profile of obese male rats

Sidi Mohammed YAZIT, Fouzia AMAMOU, Radjaa Kawtar MEZIANE, Zoubida SOUALEM-MAMI, Hamadi Abderrahmane LAZZOUNI, Daoudi CHABANE SARI

doi:10.46325/jnpra.v4i02.74

Authors

Sidi Mohammed YAZIT, Fouzia AMAMOU, Radjaa Kawtar MEZIANE, Zoubida SOUALEM-MAMI, Hamadi Abderrahmane LAZZOUNI, Daoudi CHABANE SARI Natural products laboratory (LAPRONA), Department of Biology, SNV-STU Faculty, Abou Bekr Belkaïd University

DOI:

https://doi.org/10.46325/jnpra.v4i02.74

Keywords:

Obesity; hepatic steatosis: colocynth oil; liver; PUFAs.

Abstract

Citrullus colocynthis is a plant of the cucurbitaceae family native to arid soils. It contains around 17℅ of oil, rich in essential polyunsaturated fatty acids with regulatory powers for certain metabolic pathologies such as hypercholesterolemia. The aim of this work is to test the effect of colocynth oil (CO) on hepatic lipids in Wistar rats fed hyper-fatty diets supplemented with (CO), compared with other rats fed control diets based on 8 ℅ sunflower oil (SO). To this end, male Wistar rats weighing 80±5g were divided into four batches. The rats were fed different diets (R) for 2 months (D1: 16℅ casein + 8℅ SO, D2: 16℅ casein+ 8℅ CO, D3: 16℅ casein+ 30℅ fat+ 8℅ SO, D4: 16℅ casein+ 30℅ fat+ 8℅ CO), the weights of the rats and the quantity of food ingested were taken daily, at the end of the diet the rats were dissected and the livers recovered for hepatic lipid assays using the folch method. The results showed a reduction in triglycerides in the liver of rats fed diets containing oil of colocynth (37%) and reduced blood triglyceride (12%) and cholesterol (6%), whereas rats fed high-fat diets had elevated hepatic and blood lipid levels. Colocynth oil has a corrective and/or protective effect on obesity and its complications by preventing the accumulation of fat in the liver, thereby preventing hepatic steatosis.

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