In vitro antioxidant and antidiabetic activities of the hydro-acetone extracts of Ricinus communis and Teucrium polium from Tlemcen area


  • Nabila BENARIBA, Zohra FEKHIKHER, Radia BRIXI-GORMAT, Hanane BENRAMDANE, Houda YOUBI , Ibtissam KOUAR , Hanane MILOUDI , Soumia MEHARRAR Laboratory of Antibiotic, Antifungal: Physico-Chemistry, Synthesis, and Biological Activity. Department of Biology, SNV-STU Faculty, Abou Bekr Belkaïd University, BP 119, 13000 Tlemcen, Algeria
  • Imad Abdelhamid EL HACI Center of Scientific and Technical Research in Physico-Chemical Analyses (CRAPC), BP 384 Bou-Ismail, 42004 Tipaza, Algeria; Laboratory of Natural Products, Department of Biology, SNV-STU Faculty, Abou Bekr Belkaïd University, BP 119, 13000 Tlemcen, Algeria.
  • Houria MEDJDOUB , Rachid AZZ Laboratory Antibiotic, Antifungal, Physico- Chemistry, Synthesis and Biological Activity, Department of Biology, Faculty of Natural Sciences and Life Sciences of the Earth and the Universe, University of Tlemcen , Algeria.



Ricinus communis; Teucrium polium; total polyphenol contents; DPPH; FRAP; α-amylase.


The aim of the present study was to determine total phenolic and total flavonoid contents in hydro-acetone extracts from the roots of Ricinus communis and the aerial part of Teucrium polium, and to determine in vitro their antioxidant and antidiabetic activities using DPPH, FRAP, and α-amylase activity assay, respectively. The obtained results reveled that R. communis roots hydro-acetone extract contains high contents of polyphenols (499.55 ± 0.02 µg GAE/mg DE) and flavonoids (28.21 ± 0.01 µg Cat eq/mg DE) than T. polium aerial part extracts. Both plant extracts showed in vitro antioxidant and antidiabetic activities, where R. communis showed a potent free radical scavenging activity (DPPH IC50=2.01 ± 0.01 µg/mL) and high iron reduction capacity (FRAP EC50=41.32 ± 0.01 µg/mL) more than T. polium extract (DPPH IC50= 7.40 ± 0.01 µg/mL; FRAP EC50=74.63 ± 0.01 µg/mL). In addition, in α-amylase activity assay T. polium was more efficient in inhibiting this enzyme (EC50= 924 ± 0.19 µg/mL) compared to R. communis extract (EC50= 1300 ± 0.03 µg/mL).


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How to Cite

Nabila BENARIBA, Zohra FEKHIKHER, Radia BRIXI-GORMAT, Hanane BENRAMDANE, Houda YOUBI , Ibtissam KOUAR , Hanane MILOUDI , Soumia MEHARRAR, Imad Abdelhamid EL HACI, & Houria MEDJDOUB , Rachid AZZ. (2024). In vitro antioxidant and antidiabetic activities of the hydro-acetone extracts of Ricinus communis and Teucrium polium from Tlemcen area. Journal of Natural Product Research and Applications, 3(02), 34–46.